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Updated: Apr 22, 2026

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
Published on: June 28, 2024
Preterm delivery and low maternal serum cholesterol level: Any correlation?
Ayodeji A Oluwole1, Maymunah A Adegbesan-Omilabu1, Kehinde S Okunade1
1Department of Obstetrics and Gynaecology, Lagos University Teaching Hospital, Lagos, Nigeria.
Background:
The study assessed whether low maternal serum cholesterol during early pregnancy is associated with preterm delivery.
Patients And Methods:
It was a prospective observational cohort study involving pregnant women at gestational age of 14-20 weeks over a period of 12 months. Blood samples were obtained to measure total serum cholesterol concentrations and the sera were then analysed enzymatically by the cholesterol oxidase: p-aminophenazone (CHOD PAP) method.
Results:
The study showed an incidence of 5.0% for preterm delivery in the low risk study patients. Preterm birth was 4.83-times more common with low total maternal cholesterol than with midrange total cholesterol (11.8% versus 2.2%, P = 0.024).
Conclusion:
Low maternal serum cholesterol (hypocholesterolaemia) is associated with preterm delivery. Optimal maternal serum cholesterol during pregnancy may have merit, therefore pregnant women should be encouraged to follow a healthy, balanced diet.
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