Concomitant hypo-hyperdontia with an endocrine etiology.

Area of Science:

• Dentistry
• Human Genetics
• Endocrinology

Background:

• Concomitant hypohyperdontia, characterized by the co-occurrence of hypodontia (missing teeth) and supernumerary teeth (extra teeth), is an uncommon dental anomaly.
• The etiology of concomitant hypohyperdontia remains largely unknown, prompting investigations into potential underlying factors.
• Hypodontia and supernumerary teeth are distinct developmental disturbances, making their simultaneous occurrence particularly noteworthy.

Observation:

• This report details an exceptionally rare case of a patient presenting with both multiple supernumerary teeth and multiple missing teeth.
• The observed hypodontia involved bilateral maxillary second premolars and bilateral mandibular second molars.
• The patient also had a history of subclinical hypothyroidism, suggesting a potential systemic influence.

Findings:

• The case demonstrates the simultaneous presence of both hypodontia and supernumerary teeth within the same individual.
• The patient exhibited a pattern of missing teeth in specific locations (maxillary second premolars, mandibular second molars) alongside the presence of extra teeth.
• A history of subclinical hypothyroidism was noted in the patient, raising questions about systemic disease involvement.

Implications:

• This case suggests that systemic conditions, such as subclinical hypothyroidism, may play a role in the etiology of concomitant hypohyperdontia.
• Further research is warranted to explore the potential link between endocrine disorders and the development of combined tooth number anomalies.
• Understanding the etiology of such rare conditions can inform diagnostic approaches and potentially lead to earlier interventions for patients with dental anomalies.