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Acitretin monotherapy in Darier's disease
R J van Dooren-Greebe1, P C van de Kerkhof, R Happle
1Department of Dermatology, University of Nijmegen, The Netherlands.
The British Journal of Dermatology
|September 1, 1989
Summary
Acitretin effectively treats Darier's disease, with four of five patients showing significant improvement. Initial dosing of 10-25 mg daily is recommended to avoid adverse reactions like isomorphic responses.
Area of Science:
- Dermatology
- Pharmacology
- Genetic Disorders
Background:
- Darier's disease is a rare genetic skin disorder.
- Acitretin is a second-generation retinoid used for various skin conditions.
Observation:
- Five patients with Darier's disease were treated with acitretin.
- Initial dosage was 35 mg daily, adjusted based on clinical response.
Findings:
- Four out of five patients experienced marked improvement, with some achieving total clearance.
- Two patients developed isomorphic reactions, indicating a relative overdose, which resolved upon dose reduction.
Implications:
- Acitretin shows therapeutic potential for Darier's disease.
- Starting acitretin treatment at a lower dose (10-25 mg daily) with gradual adjustment may minimize adverse effects and optimize patient outcomes.