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Related Experiment Videos

Exfoliative dermatitis due to nifedipine.

N J Reynolds1, S K Jones, J Crossley

  • 1Department of Dermatology, Bristol Royal Infirmary, U.K.

The British Journal of Dermatology
|September 1, 1989
PubMed
Summary

Nifedipine can cause a generalized skin eruption with lichenoid histological features. A case study confirmed nifedipine as the cause of a patient's skin reaction.

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Reno-vascular hypertension is a condition affecting kidney blood vessels.
  • Nifedipine is a calcium channel blocker commonly prescribed for hypertension.

Observation:

  • A 63-year-old female patient with reno-vascular hypertension presented with a widespread skin rash.
  • Skin biopsy revealed lichenoid histological features.

Findings:

  • The generalized skin eruption was determined to be induced by nifedipine.
  • A repeat nifedipine challenge confirmed it as the causative agent.

Implications:

  • This case highlights nifedipine as a potential cause of drug-induced skin reactions.
  • Clinicians should consider nifedipine when evaluating patients with similar dermatological presentations.

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