Association between adiponectin receptor 2 gene polymorphisms and cerebral infarction

Area of Science:

• Genetics
• Neurology
• Cardiovascular Disease

Background:

• Ischemic stroke is a leading cause of disability and death worldwide.
• Genetic factors play a significant role in the pathogenesis of ischemic stroke.
• The adiponectin receptor 2 (ADIPOR2) gene is implicated in metabolic and vascular functions.

Purpose of the Study:

• To investigate the association between the ADIPOR2 gene rs12342 polymorphism and the risk of ischemic stroke.
• To determine if specific genotypes of rs12342 influence susceptibility to ischemic stroke.

Main Methods:

• Case-control study involving 300 ischemic stroke patients and 320 healthy controls.
• Genotyping of the ADIPOR2 rs12342 polymorphism using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
• Statistical analysis to compare genotype and allele frequencies and calculate odds ratios.

Main Results:

• Significantly higher frequencies of the AA genotype and A allele of rs12342 were observed in ischemic stroke patients compared to controls (P < 0.01).
• Carriers of the AA genotype had a 1.786-fold increased risk of ischemic stroke compared to GG genotype carriers (OR = 1.786, 95% CI: 1.432-2.775; P = 0.013).
• This association remained significant after adjusting for confounding factors (OR = 1.874, 95% CI: 1.221-2.765; P = 0.012).

Conclusions:

• The AA genotype and A allele of the ADIPOR2 rs12342 polymorphism are potential risk factors for ischemic stroke.
• These genetic variations may contribute to the development of atherosclerosis cerebral infarction.
• Further research is warranted to elucidate the underlying mechanisms.