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Linear motif-mediated interactions have contributed to the evolution of modularity in complex protein interaction

Inhae Kim1, Heetak Lee1, Seong Kyu Han1

  • 1Department of Life Sciences, Pohang University of Science and Technology, Pohang, Korea.

Plos Computational Biology
|October 10, 2014
PubMed
Summary

Weak domain-linear motif interactions connect biological modules, driving the evolution of complex protein-protein interaction networks. This molecular division of labor is key to understanding network architecture.

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