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Related Experiment Video

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Author Spotlight: Streamlining Visual Dynamics to Simplify Molecular Dynamics Simulations Using Gromacs

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SMART: recent updates, new developments and status in 2015.

Ivica Letunic¹, Tobias Doerks², Peer Bork³

¹Biobyte solutions GmbH, Bothestr 142, 69126 Heidelberg, Germany.

Nucleic Acids Research

|October 11, 2014

Summary

This summary is machine-generated.

The Simple Modular Architecture Research Tool (SMART) database now annotates over 100 million protein domains across 2031 species. This update enhances protein domain identification and visualization for researchers.

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Area of Science:

Bioinformatics
Computational Biology
Molecular Biology

Background:

The Simple Modular Architecture Research Tool (SMART) is a vital web resource for protein domain identification and annotation.
Protein domain architecture exploration is crucial for understanding protein function and evolution.

Purpose of the Study:

To present the updated version of the SMART database and its new features.
To highlight improvements in protein domain models, database synchronization, and genomic annotation capabilities.

Main Methods:

Manual curation of protein domain models.
Synchronization with major protein databases (UniProt, Ensembl, STRING).
Expansion of the 'Genomic' mode to include a larger number of species.
Redesign of analysis results pages and development of a new vector-based display engine for protein schematics.

Main Results:

SMART now contains over 1200 manually curated protein domain models, with approximately 200 new additions.
The database annotates over 100 million protein domains and features.
The 'Genomic' mode now covers 2031 species, a significant increase from the previous release.
Redesigned results pages and improved visualization tools enhance user experience.

Conclusions:

The updated SMART resource provides enhanced capabilities for protein domain analysis and exploration.
Improvements in data scope and visualization tools facilitate deeper insights into protein architectures.
SMART continues to be an essential tool for researchers in bioinformatics and molecular biology.