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Increased risk of stroke among hip fracture patients: a nationwide cohort study

C-H Tsai1, C-L Lin, H-C Hsu

  • 1Graduate Institute of Clinical Medicine, China Medical University, Taichung, Taiwan.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|October 11, 2014
PubMed

Insights

Hip fracture significantly increases the risk of stroke, particularly in younger men and those with cardiovascular conditions. This association highlights the need for vigilant monitoring post-hip fracture to prevent cerebrovascular events.

Area of Science:

  • Orthopedics
  • Neurology
  • Epidemiology

Background:

  • Hip fractures are linked to increased morbidity.
  • Limited data exist on the stroke risk following hip fractures.
  • This study aimed to investigate the association between hip fracture and subsequent stroke risk.

Purpose of the Study:

  • To determine if hip fracture is an independent risk factor for stroke.
  • To identify specific patient subgroups with a higher risk of stroke after hip fracture.

Main Methods:

  • A large nationwide cohort study using universal insurance claims data.
  • Identified 6013 hip fracture patients and 23,802 controls (2000-2010).
  • Estimated stroke incidence and risk in both cohorts until 2011.

Main Results:

  • Hip fracture patients had a 1.69-fold higher stroke incidence (adjusted HR=1.54).
  • Increased risk observed for both ischemic and hemorrhagic stroke.
  • Higher stroke risk in patients with diabetes, hypertension, heart failure, or using diuretics and angiotensin II receptor blockers (ARBs).

Conclusions:

  • Hip fracture is an independent predictor of subsequent stroke.
  • Younger patients, men, and those with cardiovascular comorbidities face a greater risk.
  • Specific medications like diuretics and ARBs are associated with elevated stroke risk post-hip fracture.
Abstract

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