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A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus
Published on: June 23, 2022
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Equine herpesvirus 1 myeloencephalopathy
Nicola Pusterla1, Gisela Soboll Hussey2
1Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA.
The Veterinary Clinics of North America. Equine Practice
|October 11, 2014
Summary
Equine myeloencephalopathy (EHM), caused by equine herpesvirus 1 (EHV-1), leads to significant losses. Understanding EHV-1 outbreaks is crucial for improving diagnosis, treatment, and prevention strategies.
Area of Science:
- Veterinary Virology
- Equine Infectious Diseases
Background:
- Equine herpesvirus 1 (EHV-1) causes equine myeloencephalopathy (EHM), a serious neurological disease.
- EHM outbreaks result in substantial economic and welfare losses in equine populations.
- Recent field outbreaks in North America and Europe have increased focus on EHV-1.
Purpose of the Study:
- To review current data on the cause, epidemiology, pathogenesis, and immunity of EHV-1.
- To update knowledge on diagnostic procedures, treatment options, and prevention strategies for EHM.
- To emphasize recent findings and their implications for managing EHV-1 infections.
Main Methods:
- Review of experimental studies on EHV-1.
- Analysis of data from field outbreaks of EHM.
- Synthesis of recent scientific literature on EHV-1 and EHM.
Main Results:
- EHV-1 is a highly contagious virus with significant neurological impact.
- Outbreaks necessitate reevaluation of current disease management protocols.
- Improved understanding of pathogenesis aids in targeted interventions.
Conclusions:
- Effective management of EHM requires a comprehensive approach integrating diagnostics, treatment, and biosecurity.
- Continued research into EHV-1 is vital for mitigating its impact on equine health.
- Enhanced biosecurity measures are critical for preventing EHV-1 transmission.
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