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Pulmonary functional magnetic resonance imaging: asthma temporal-spatial maps.

Sarah Svenningsen1, Fumin Guo2, Miranda Kirby3

  • 1Imaging Research Laboratories, Robarts Research Institute, Western University, 1151 Richmond St North, London, Ontario, Canada N6A 5B7; Department of Medical Biophysics, The University of Western Ontario, London, Ontario, Canada.

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Summary

New temporal-spatial maps from hyperpolarized helium-3 MRI quantify ventilation defects in asthma. These maps can guide personalized asthma therapy by identifying persistent and intermittent defects.

Keywords:
hyperpolarized (3)He magnetic resonance imagingimage-guided therapylung functionsthmaventilation defect

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Area of Science:

  • Pulmonary Medicine
  • Medical Imaging
  • Respiratory Physiology

Background:

  • Hyperpolarized helium-3 (3He) MRI reveals ventilation heterogeneity in asthma.
  • Previous findings lacked application in treatment studies or personalized therapy.

Purpose of the Study:

  • To develop pulmonary ventilation temporal-spatial maps using (3)He MRI data.
  • To enable measurement, optimization, and guidance of asthma therapy.

Main Methods:

  • Seven asthmatics underwent spirometry and (3)He MRI on three separate occasions.
  • A registration and segmentation pipeline created 3D temporal-spatial pulmonary function maps.
  • Ventilation defects were classified as persistent or intermittent and quantified.

Main Results:

  • Temporal-spatial maps identified both persistent and intermittent ventilation defects.
  • Intermittent defects were significantly greater in posterior and inferior lung regions.
  • Defect percentages strongly correlated with spirometry measures (FEV1/FVC).

Conclusions:

  • (3)He MRI-derived temporal-spatial maps can quantify asthma ventilation defects.
  • These maps serve as intermediate endpoints and therapeutic targets for asthma management.