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The miRNA23b-regulated signaling network as a key to cancer development--implications for translational research and

Vignesh Viswanathan1,2, Jeremy Fields3, Bruce M Boman4,5

  • 1Department of Biological Sciences, University of Delaware, 118, Wolf Hall, Newark, DE, 19716, USA.

Journal of Molecular Medicine (Berlin, Germany)
|October 11, 2014
PubMed

Insights

MicroRNA23b (miR23b) is vital for cell functions and immunity. Its dysregulation is linked to diseases like cancer, affecting cell signaling and potentially offering new diagnostic and therapeutic strategies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNA23b (miR23b) is a pleiotropic microRNA involved in regulating cellular functions, differentiation, and immune responses.
  • Dysregulation of miR23b expression is increasingly implicated in various diseases, particularly cancer.
  • miR23b influences key signaling pathways, including TGF-beta and Notch, which are critical for cancer cell malignancy.

Purpose of the Study:

  • To review the multifaceted roles of miR23b in cellular physiology and disease.
  • To explore the association between miR23b dysregulation and cancer development and progression.
  • To discuss the potential of miR23b as a biomarker and therapeutic target in oncology.

Main Methods:

  • Comprehensive literature review of studies investigating miR23b.
  • Analysis of miR23b's regulatory mechanisms in cellular processes.
  • Examination of miR23b's involvement in cancer-related signaling pathways.

Main Results:

  • miR23b regulates cell differentiation, immune responses, and physiological functions.
  • Aberrant miR23b expression contributes to cancer by modulating genes in TGF-beta and Notch pathways, affecting cell motility and invasiveness.
  • miR23b is linked to cancer stem cells and chemoresistance.

Conclusions:

  • miR23b plays a critical role in maintaining cellular homeostasis and immune function.
  • Dysregulated miR23b is a significant factor in cancer pathogenesis, influencing key oncogenic pathways.
  • miR23b holds promise for the development of novel cancer diagnostics and therapeutics.
Keywords:
Cancer stem cellsMiR23bSignaling pathways

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