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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
[Relationship between dyslipidemia and severity in preeclampsia]
Jesús Duarte-Mote1, Carolina Perez-Torres, Rogelio Espinosa-López
1Servicio de Medicina Interna, Hospital General Regional 220 "General José Vicente Villada", Instituto Mexicano del Seguro Social, Instituto Mexicano del Seguro Social, Toluca, México. maria.romerof@imss.gob.mx, sromero61@hotmail.com.
Background:
It has been found that the cholesterol and triglyceride values are higher in preeclampsia than in normal pregnancy, even though it is unclear whether these levels are related to the severity. The aim of this study was to determine the correlation between dyslipidemia and severity in preeclampsia.
Methods:
Comparative cross-sectional study in 200 patients, 100 with normal pregnancy and 100 with preeclampsia. The age, gynecological and obstetric history, total cholesterol and triglycerides were identified. Descriptive statistics were used: Student's t test for comparing the group of patients with preeclampsia and normal pregnancies, and ANOVA and odds ratio for the subanalysis of mild and severe preeclampsia.
Results:
No statistically significant differences in age or cholesterol were found. Triglycerides showed a statistically significant difference: they were higher in relation to the severity of preeclampsia (normal pregnancy: 245 mg; mild preeclampsia: 308 mg; severe preeclampsia: 349 mg).
Conclusions:
Elevated levels of cholesterol and triglycerides in patients with preeclampsia showed no consistent relationship with the severity of preeclampsia.
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