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Prior knowledge influences on hippocampus and medial prefrontal cortex interactions in subsequent memory
Oded Bein1, Niv Reggev1, Anat Maril2
1Departments of Cognitive Science, The Hebrew University of Jerusalem, Israel.
Neuropsychologia
|October 11, 2014
Summary
Prior knowledge impacts memory encoding. Positively correlated hippocampus-medial prefrontal cortex activity uniquely aids remembering schema-inconsistent events, suggesting a broader network for encoding novel information.
Area of Science:
- Cognitive Neuroscience
- Neurobiology of Memory
- Systems Neuroscience
Background:
- Prior knowledge influences how new events are encoded into memory.
- Theoretical frameworks propose distinct neural mechanisms for encoding schema-consistent versus schema-inconsistent information.
- Previous research has not fully elucidated the role of inter-regional functional connectivity in memory for schema-inconsistent events.
Purpose of the Study:
- To investigate the role of hippocampus (HC) and medial prefrontal cortex (mPFC) functional connectivity in the subsequent memory of schema-consistent and schema-inconsistent events.
- To examine how functional connectivity at encoding differs from baseline for remembered versus forgotten items.
- To identify the neural network involved in encoding schema-inconsistent events.
Main Methods:
- Participants encoded semantically related (schema-consistent) and unrelated (schema-inconsistent) word pairs.
- A surprise recognition test assessed memory performance.
- Subsequent memory analysis focused on functional connectivity between HC, mPFC, and other cortical regions during encoding.
Main Results:
- Subsequent memory modulated HC-mPFC connectivity specifically for schema-inconsistent events.
- Remembered schema-inconsistent events showed positive HC-mPFC correlation, while forgotten ones did not differ from baseline.
- Positive mPFC connectivity with visual and parietal regions mediated subsequent memory for schema-inconsistent items.
Conclusions:
- Schema-inconsistent events are encoded via a network involving the hippocampus, medial prefrontal cortex, and other cortical regions.
- Distinct functional connectivity patterns, particularly between HC and mPFC, are crucial for remembering schema-inconsistent information.
- These findings support theoretical frameworks linking specific neural interactions to the memory encoding of novel or unexpected events.
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