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Updated: Apr 22, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

A systemic disease un…suspected by physical examination.

Cátia Costa¹, Davide Severino¹, Maria Luz Pitta¹

¹Hospital Santarém, Santarém, Portugal.

BMJ Case Reports

|October 11, 2014

Summary

A 73-year-old man with unstable angina was diagnosed with cardiac amyloidosis due to light-chain amyloidosis (AL) and multiple myeloma. This rare condition caused significant heart thickening and coronary artery disease.

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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

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Published on: May 16, 2025

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

Area of Science:

Cardiology
Hematology
Oncology

Background:

A 73-year-old male presented with unstable angina.
He had a history of macroglossia, attributed to hypothyroidism.

Observation:

Physical examination revealed significant macroglossia.
ECG showed sinus rhythm with low voltage criteria.
Transthoracic echocardiography demonstrated preserved left ventricular function with marked wall thickening and reduced basal segment strain.

Findings:

Coronary angiography identified a 90% stenosis in the right coronary artery, treated with stenting.
Further investigations confirmed systemic amyloid light-chain (AL) amyloidosis with cardiac involvement.
The amyloidosis was associated with multiple myeloma.

Implications:

This case highlights the importance of considering systemic infiltrative diseases in patients with cardiac symptoms and unusual physical findings.
Early diagnosis of AL amyloidosis and multiple myeloma is crucial for timely hematologic and cardiac management.
Multidisciplinary collaboration between cardiology, hematology, and oncology is essential for optimal patient outcomes.