Serum resistin concentrations in children with type 1 diabetes mellitus--negative relation to body fat mass

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Katarzyna Anna Majewska1, Dominik Majewski, Bogda Skowrońska

  • 1kswiton@poczta.onet.pl.

Endokrynologia Polska
|October 11, 2014
PubMed

Insights

Children with type 1 diabetes have lower resistin levels, which correlate negatively with body fat. This suggests disrupted hormonal regulation between fat tissue and insulin production in type 1 diabetes.

Area of Science:

  • Endocrinology
  • Metabolic disorders
  • Pediatric research

Background:

  • Insulin regulates adipose tissue, while adipokines influence insulin action and glucose regulation.
  • Type 1 diabetes mellitus (t1DM) requires exogenous insulin, impacting natural physiological balances.
  • The effect of t1DM on adipose tissue secretory function requires further investigation.

Purpose of the Study:

  • To evaluate serum resistin concentrations in children with t1DM.
  • To assess the relationship between resistin levels and body fat mass in pediatric t1DM patients.

Main Methods:

  • Study included 75 children with t1DM and 20 healthy controls.
  • Measurements included serum resistin, glycated hemoglobin, growth parameters, and body composition via bioelectrical impedance analysis.
  • Statistical analysis compared resistin levels and correlations with body fat, age, disease duration, metabolic control, and insulin dosage.

Main Results:

  • Children with t1DM exhibited significantly lower serum resistin concentrations compared to controls (p < 0.001).
  • Resistin levels negatively correlated with body fat mass (p = 0.022) and age (p = 0.022) in the t1DM group.
  • No direct correlation was found between resistin levels and disease duration, glycated hemoglobin, or insulin dosage.

Conclusions:

  • Diminished serum resistin in pediatric t1DM may stem from disrupted physiological adipo-insular regulation.
  • The observed negative correlation between resistin and body fat is independent of disease duration, metabolic control, and insulin therapy.
  • These findings highlight altered adipokine signaling in children with type 1 diabetes.
Abstract

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