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Relationship between macular inner retinal layer thickness and corresponding retinal sensitivity in normal eyes
Makoto Araie1, Hitomi Saito1, Atsuo Tomidokoro2
1Kanto Central Hospital of The Mutual Aid Association of Public School Teachers, Tokyo, Japan Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Investigative Ophthalmology & Visual Science
|October 11, 2014
Summary
In normal eyes, thicker macular inner retinal layers, specifically the ganglion cell-inner plexiform layer (GCIPL) and ganglion cell complex (GCC), are weakly associated with higher standard automated perimetry (SAP) sensitivity.
Area of Science:
- Ophthalmology
- Neuroscience
- Medical Imaging
Background:
- Standard automated perimetry (SAP) sensitivity is known to correlate with macular inner retinal layer thickness in glaucoma.
- The relationship between SAP sensitivity and macular inner retinal layer thickness in healthy eyes requires further investigation.
Purpose of the Study:
- To determine if a significant correlation exists between standard automated perimetry (SAP) sensitivity and macular inner retinal layer thickness in normal eyes.
Main Methods:
- Spectral-domain optical coherence tomography (SD-OCT) was used to measure macular ganglion cell-inner plexiform layer (GCIPL) and ganglion cell complex (GCC) thickness in 195 normal subjects.
- These measurements were correlated with mean SAP sensitivity at corresponding test points using multiple regression analysis, controlling for age, refraction, disc size, sex, and eye laterality.
Main Results:
- A significant, albeit weak, correlation was found between GCIPL and GCC thickness and SAP sensitivity in normal eyes.
- Age was significantly correlated with both GCIPL and GCC thickness, while refraction showed a significant correlation with GCIPL thickness.
Conclusions:
- Macular GCIPL and GCC thickness are weakly but significantly associated with higher SAP sensitivity in normal eyes.
- This finding suggests a potential link between inner retinal structure and visual field sensitivity even in the absence of disease.
