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Manipulation of Ploidy in Caenorhabditis elegans

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Published on: March 15, 2018

True cyclopia-very rare anomaly.

K R Srinivasan¹, N Abraham Ratna Joseph², P Koteswary³

¹Professor, Department of Anatomy, Vinayaka Missions Kirupananda Variyar Medical College , Salem, Tamilnadu, India .

Journal of Clinical and Diagnostic Research : JCDR

|October 11, 2014

Summary

A rare case of true cyclopia, a congenital anomaly where eyeballs fuse into a single midline organ, was identified in a female infant during a postmortem examination. This finding highlights the spectrum of severe congenital malformations.

Keywords:

Cephalic presentation Gestation Hexcaprone Intrauterine contraceptive device Micrognathia Osseous defects Proboscis Respiratory distress

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Area of Science:

Medical Science
Developmental Biology
Pathology

Background:

Congenital anomalies represent a significant global health concern, impacting infant mortality and morbidity.
Cyclopia, a severe form of holoprosencephaly, is characterized by the failure of the embryonic forebrain to divide properly.

Observation:

A female infant presenting with true cyclopia was discovered during a routine postmortem examination.
The infant exhibited complete fusion of both eyeballs into a single midline facial structure.

Findings:

The infant weighed 2910 g and was born at 35 weeks gestation.
The infant survived for less than 20 minutes post-birth.
This case originated from the mother's fourth pregnancy.

Implications:

This case underscores the importance of understanding the genetic and environmental factors contributing to holoprosencephaly.
Accurate pathological examination is crucial for documenting and studying rare congenital malformations.
Further research into the developmental pathways of facial fusion can inform future diagnostic and therapeutic strategies.