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Hyperhomocysteinemia, Insulin Resistance and High HS- CRP Levels in Prehypertension

Prashanth Talikoti1, Zachariah Bobby2, Abdoul Hamide3

  • 1Assistant Professor, Department of Biochemistry, Meenakshi Medical College Hospital and Research institute , Kanchipurum, India .

Journal of Clinical and Diagnostic Research : JCDR
|October 11, 2014
PubMed

Insights

Pre-hypertension is linked to higher levels of homocysteine, insulin resistance, and C-reactive protein (hs-CRP). Early detection and lifestyle changes are crucial for managing pre-hypertension and preventing cardiovascular disease.

Area of Science:

  • Cardiovascular Health
  • Metabolic Syndrome
  • Inflammation Markers

Background:

  • Pre-hypertension, defined as blood pressure between 120-139/80-89 mm Hg, is increasingly prevalent in India.
  • Elevated homocysteine, C-reactive protein (hs-CRP), and insulin resistance are implicated in hypertension development.
  • Individuals with pre-hypertension face a higher risk of cardiovascular disease compared to those with normal blood pressure.

Purpose of the Study:

  • To evaluate serum homocysteine, hs-CRP levels, and insulin resistance in pre-hypertensive individuals.
  • To compare these markers between pre-hypertensive and normotensive subjects.

Main Methods:

  • Sixty pre-hypertensive and 32 normotensive subjects were recruited based on JNC 7 guidelines.
  • Analysis included serum homocysteine, vitamin B12, folate, insulin, hs-CRP, and lipid profiles.
  • Independent t-tests and Pearson correlation analyses were performed.

Main Results:

  • Pre-hypertensives showed significantly increased serum homocysteine, insulin resistance, and hs-CRP.
  • Elevated total cholesterol, triglycerides (TG), LDL-C, and VLDL-C were observed in pre-hypertensives.
  • Serum homocysteine positively correlated with systolic blood pressure (SBP), while vitamin B12 and folate showed negative correlations.

Conclusions:

  • Established cardiovascular risk factors—homocysteine, insulin resistance, and hs-CRP—are elevated in pre-hypertension.
  • Early identification and lifestyle modifications can potentially reduce the risk or delay the onset of hypertension and cardiovascular complications.
Abstract

Keywords:
HyperhomocysteinemiaInsulin resistancePrehypertensionhs-CRP

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