Related Experiment Video
Updated: Apr 22, 2026

Author Spotlight: Exploring the Mysteries of Sichuan's Herbal Medicine in Chinese Medicine Research
Published on: March 1, 2024
Anti cariogenic effect of terminalia chebula
Vidhya Rekha1, Jayamathi2, RamaKrishnan3
1Post Graduate Student, Department of Public Health Dentistry, SRM Dental College , Chennai, Tamil Nadu, India .
Terminalia chebula extract demonstrated significant antimicrobial activity against oral pathogens linked to dental caries. This traditional medicine shows promise as an effective alternative agent for oral health.
Area of Science:
- Phytochemistry
- Microbiology
- Dentistry
Background:
- Terminalia chebula is a traditional medicine with diverse therapeutic activities.
- This study investigates its antimicrobial potential against caries-causing oral pathogens.
Purpose of the Study:
- To evaluate the antimicrobial properties of Terminalia chebula extract.
- To assess its effect on oral pH and microbial load in high-caries-risk patients.
Main Methods:
- Antimicrobial activity assessed using the Kirby-Bauer method.
- Total phenol and flavonoid content analyzed.
- High-caries-risk patients rinsed with Terminalia chebula extract; salivary pH and microbial counts were measured pre- and post-rinse.
Main Results:
- Extract contained significant levels of total phenols (21.33 ±1.633) and flavonoids (23.17 ± 2.317).
- Salivary pH increased post-rinse, indicating a shift towards a less acidic oral environment.
- Significant reduction in oral microbial load observed after rinsing with the extract.
Conclusions:
- Terminalia chebula exhibits potent antimicrobial activity against oral pathogens.
- It effectively reduces microbial load and improves salivary pH, suggesting its potential as an alternative agent for managing dental caries.
Related Concept Videos
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
Cholinergic Antagonists: Therapeutic Uses
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
Cholinergic Antagonists: Pharmacological Actions
Gastrointestinal Effects: Antimuscarinics reduce gut contractions, increase gastric emptying, and slow intestinal transit. They partly inhibit gastric acid secretion...
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Two synthetic agonists of THC,...
Indirect-Acting Cholinergic Agonists: Pharmacological Actions
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
Cholinergic Antagonists: Pharmacokinetics