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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
Radiation oncology in vitro: trends to improve radiotherapy through molecular targets
Natália Feofanova1, Jony Marques Geraldo2, Lídia Maria de Andrade3
1Research Institute of Internal and Preventive Medicine, FSBI, Boris Bogatkov Street 175/1, Novosibirsk 630089, Russia.
Abstract:
Much has been investigated to improve the beneficial effects of radiotherapy especially in that case where radioresistant behavior is observed. Beyond simple identification of resistant phenotype the discovery and development of specific molecular targets have demonstrated therapeutic potential in cancer treatment including radiotherapy. Alterations on transduction signaling pathway related with MAPK cascade are the main axis in cancer cellular proliferation even as cell migration and invasiveness in irradiated tumor cell lines; then, for that reason, more studies are in course focusing on, among others, DNA damage enhancement, apoptosis stimulation, and growth factors receptor blockages, showing promising in vitro results highlighting molecular targets associated with ionizing radiation as a new radiotherapy strategy to improve clinical outcome. In this review we discuss some of the main molecular targets related with tumor cell proliferation and migration as well as their potential contributions to radiation oncology improvements.
Insights
Researchers are exploring molecular targets to overcome radioresistant cancer. Targeting pathways like MAPK can enhance radiotherapy effectiveness and improve patient outcomes.
Area of Science:
- Radiation Oncology
- Molecular Biology
- Cancer Therapeutics
Background:
- Radiotherapy is a cornerstone of cancer treatment, but radioresistance limits its efficacy.
- Identifying molecular targets is crucial for developing novel therapeutic strategies.
- Mitogen-activated protein kinase (MAPK) signaling pathways are implicated in cancer cell proliferation and migration.
Purpose of the Study:
- To review molecular targets that can enhance the efficacy of radiotherapy.
- To discuss the role of molecular alterations in radioresistant cancer.
- To highlight potential strategies for improving clinical outcomes in radiation oncology.
Main Methods:
- Literature review of studies investigating molecular targets in radiotherapy.
- Analysis of research focusing on signal transduction pathways, particularly MAPK.
- Examination of in vitro results related to DNA damage, apoptosis, and receptor blockade.
Main Results:
- Molecular targets associated with tumor cell proliferation and migration show therapeutic potential.
- Interventions targeting MAPK pathways, DNA damage, apoptosis, and growth factor receptors demonstrate promising in vitro results.
- These molecular strategies represent a novel approach to radiotherapy.
Conclusions:
- Targeting specific molecular pathways can overcome radioresistance in cancer.
- Enhancing DNA damage, stimulating apoptosis, and blocking growth factor receptors are promising strategies.
- Molecularly targeted radiotherapy holds potential for improving clinical outcomes.
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