A dual functional AEE fluorogen as a mitochondrial-specific bioprobe and an effective photosensitizer for
Engui Zhao1, Haiqin Deng, Sijie Chen
1HKUST Shenzhen Research Institute, No. 9 Yuexing 1st RD, South Area, Hi-tech Park Nanshan, Shenzhen 518057, China. tangbenz@ust.hk.
Chemical Communications (Cambridge, England)
|October 11, 2014
Abstract:
We report a dual functional aggregation-enhanced emission (AEE) molecule, TPE-IQ, which could target and illuminate mitochondria in both live and fixed cells with superb selectivity and high signal-to-noise ratio. More intriguingly, TPE-IQ can serve as a photosensitizer to generate reactive oxygen species (ROS) in the mitochondria region to induce cell apoptosis.
