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Related Concept Videos

Proteomics01:33

Proteomics

7.4K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.4K

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Related Experiment Video

Updated: Apr 22, 2026

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
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Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

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Proteomics in sepsis: a pilot study.

Rita Azevedo de Paiva1, Cid Marcos David2, Gilberto Barbosa Domont3

  • 1Universidade Católica do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.

Revista Brasileira De Terapia Intensiva
|October 11, 2014
PubMed
Summary
This summary is machine-generated.

This study identified 14 differentially expressed proteins in sepsis patients, revealing key molecular pathways involved in the disease. These protein markers offer potential for improved sepsis diagnosis and understanding.

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A Data-Driven Approach to Quantifying Immune States in Sepsis
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A Data-Driven Approach to Quantifying Immune States in Sepsis

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Related Experiment Videos

Last Updated: Apr 22, 2026

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
05:28

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

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A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

595

Area of Science:

  • Proteomics
  • Molecular Biology
  • Biochemistry

Background:

  • Sepsis disrupts normal gene expression, impacting patient outcomes.
  • Genetic markers alone do not reflect dynamic biological processes.
  • Proteins are key indicators of these environmental biological processes.

Purpose of the Study:

  • To gain deeper insight into the molecular underpinnings of sepsis.
  • To identify and analyze differential serum protein expression across sepsis stages.

Main Methods:

  • Proteomic techniques were applied to serum samples from sepsis patients.
  • Serum samples underwent one-dimensional and two-dimensional gel electrophoresis.
  • Differential proteins were identified using mass spectrometry.

Main Results:

  • Fourteen differentially expressed proteins were identified across sepsis stages (sepsis, severe sepsis, septic shock).
  • A potential novel sepsis biomarker was suggested by a protein with stage-specific expression.
  • Identified proteins implicate complement, coagulation, lipid metabolism, and immune system pathways.

Conclusions:

  • Sepsis involves complex molecular disruptions affecting multiple biological pathways.
  • Differential protein expression provides valuable molecular insights into sepsis progression.
  • The identified proteins, particularly proteinase inhibitors, highlight the immune system's role in sepsis.