Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

5.2K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
5.2K
Antihypertensive Drugs: Vasodilators01:23

Antihypertensive Drugs: Vasodilators

2.5K
Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
2.5K
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

600
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
600
Vascular Resistance01:20

Vascular Resistance

13.7K
Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
13.7K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.9K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.9K
Antianginal Drugs: Nitrates and β-Blockers01:16

Antianginal Drugs: Nitrates and β-Blockers

1.9K
In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates,  such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacological treatment with a GABA(A) receptor modulator and a selective serotonin reuptake inhibitor as a mitigation strategy against aircraft noise-induced cardiovascular and neuronal damage.

British journal of pharmacology·2026
Same author

The influence of physical activity on the mental health of high school students: the chain mediating effects of social support and self-esteem.

Scientific reports·2025
Same author

Vascular effects of perivascular adipose tissue-derived chemerin in obesity-associated cardiovascular disease.

Cardiovascular diabetology·2025
Same author

Pharmacological targeting of endothelial nitric oxide synthase dysfunction and nitric oxide replacement therapy.

Free radical biology & medicine·2025
Same author

L-Citrulline Improves IGF-1 Signaling Pathway in Preeclampsia via Polyamines.

Hypertension (Dallas, Tex. : 1979)·2025
Same author

Ultrasound-assisted covalent cross-linking of egg white protein with ferulic acid: Structure, foaming, and application in chiffon cake.

Food research international (Ottawa, Ont.)·2025

Related Experiment Video

Updated: Apr 22, 2026

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries
08:58

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries

Published on: February 25, 2016

9.2K

Resveratrol and endothelial nitric oxide.

Ning Xia1, Ulrich Förstermann2, Huige Li3

  • 1Department of Pharmacology, Johannes Gutenberg University Medical Center, Obere Zahlbacher Str. 67, Mainz 55131, Germany. xianing@uni-mainz.de.

Molecules (Basel, Switzerland)
|October 11, 2014
PubMed
Summary

Resveratrol enhances cardiovascular health by boosting nitric oxide (NO) production via endothelial NO synthase (eNOS). This polyphenol improves NO bioavailability and offers protective effects against hypertension and atherosclerosis.

More Related Videos

Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
08:32

Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells

Published on: March 16, 2017

13.7K
Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
08:23

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

4.4K

Related Experiment Videos

Last Updated: Apr 22, 2026

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries
08:58

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries

Published on: February 25, 2016

9.2K
Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
08:32

Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells

Published on: March 16, 2017

13.7K
Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
08:23

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

4.4K

Area of Science:

  • Cardiovascular Science
  • Metabolic Health
  • Pharmacology

Background:

  • Endothelial nitric oxide synthase (eNOS) produces nitric oxide (NO), crucial for cardiovascular regulation.
  • Resveratrol, a polyphenol, exhibits diverse beneficial effects on cardiovascular and metabolic systems.
  • eNOS-mediated pathways are implicated in resveratrol's cardioprotective actions.

Purpose of the Study:

  • To elucidate the mechanisms by which resveratrol enhances endothelial nitric oxide synthase (eNOS) activity.
  • To investigate resveratrol's role in modulating NO bioavailability and its downstream effects.
  • To identify the molecular pathways involved in resveratrol's beneficial cardiovascular and metabolic actions.

Main Methods:

  • Investigated resveratrol's impact on eNOS expression and enzymatic activity.
  • Assessed the effect of resveratrol on NO production and oxidative stress markers.
  • Explored the involvement of SIRT1, AMPK, Nrf2, and estrogen receptors in mediating resveratrol's effects.

Main Results:

  • Resveratrol upregulates eNOS expression and stimulates its enzymatic activity.
  • Resveratrol reverses eNOS uncoupling and reduces oxidative NO inactivation, enhancing NO bioavailability.
  • Key molecular pathways including SIRT1, AMPK, Nrf2, and estrogen receptors mediate resveratrol's actions.

Conclusions:

  • Resveratrol confers cardiovascular benefits by enhancing NO production and bioavailability through multiple eNOS-dependent mechanisms.
  • Resveratrol's ability to reduce oxidative stress further potentiates its protective effects.
  • The findings highlight resveratrol as a promising agent for managing cardiovascular and metabolic diseases.