Haploidentical peripheral blood stem cell infusion in combination with chemotherapy for acute myeloid leukaemia in

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D C Bishop1, A J Johnston, J M W Kwan

  • 1Department of Haematology, Westmead Hospital, Sydney, New South Wales, Australia; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.

Internal Medicine Journal
|October 11, 2014
PubMed

Elderly patients with acute myeloid leukaemia (AML) have a poor prognosis with standard chemotherapy. Two elderly AML patients treated with infusion of family-derived partially human leukocyte antigen (HLA)-matched peripheral blood stem cells following each cycle of chemotherapy entered morphological complete remission without graft versus host disease or major toxicity. Our results support this as a non-toxic approach for inducing a graft versus leukaemia effect in patients not suitable for allogeneic transplantation. Additional resources required for donor assessment and harvest may be reduced by using banked partially HLA-matched mononuclear cells from unrelated donors.

Keywords:
acute myeloid leukaemiaadoptive cellular immunotherapyagedantineoplastic combined chemotherapy protocol/therapeutic usehematopoietic stem cell transplantation

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