Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Encephalitis l: Introduction

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...

Encephalitis ll: Pathophysiology

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...

Arboviral Encephalitis

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...

Viral Meningitis

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...

Bacterial Meningitis II: Pathophysiology

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...

Bacterial Meningitis I: Introduction

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Evaluating the effectiveness of a vancomycin stewardship programme in a level IV neonatal intensive care unit.

The Journal of hospital infection·2025

Same author

The influence of migration on women's satisfaction during pregnancy and birth: results of a comparative prospective study with the Migrant Friendly Maternity Care Questionnaire (MFMCQ).

Archives of gynecology and obstetrics·2019

Same author

Novel inactivating mutations of the DCAF17 gene in American and Turkish families cause male infertility and female subfertility in the mouse model.

Clinical genetics·2017

Same author

The Place of Atopy in the Aetiology of Acute Appendicitis in Children.

The West Indian medical journal·2017

Same author

The Effect of Thyroid-Stimulating Hormone on Tumor Size in Differentiated Thyroid Carcinoma.

The Indian journal of surgery·2016

Same author

The Investigation of Plasma Glucagon-like Peptide-1 Levels in Newly Diagnosed Type 1 Diabetic Children.

The West Indian medical journal·2016

Same journal

Prevalence of Sickle Cell Disease among Newborns in St Vincent and the Grenadines: A Retrospective Study.

The West Indian medical journal·2024

Same journal

Emergence of Zika Virus Epidemic and the National Response in Jamaica.

The West Indian medical journal·2017

Same journal

Unravelling the Paediatric and Perinatal Zika Virus Epidemic through Population-based Research.

The West Indian medical journal·2017

Same journal

The Condition of Oral Health in Regular Users of Psychoactive Substances.

The West Indian medical journal·2017

Same journal

Polypharmacy and the Risk of Malnutrition among Independently-living Elderly Persons in Trinidad.

The West Indian medical journal·2017

Same journal

Cutaneous Chylous Bubbles and Lymphatic Pilar Reflux in a Patient with Juxta-articular Dercum's Disease: A Very Rare Case.

The West Indian medical journal·2017

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 22, 2026

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Published on: July 24, 2016

Epstein-barr virus encephalitis in infancy.

F Gurbuz¹, B Gurbuz¹, A Çayir²

¹Ankara Hematology Oncology Children's Training and Research Hospital, Ankara, Turkey.

The West Indian Medical Journal

|October 11, 2014

Summary

This summary is machine-generated.

Epstein-Barr virus (EBV) encephalitis is rare in infants. This case highlights clinical findings and cerebrospinal fluid EBV DNA changes in a 10-month-old, leading to diagnosis and recovery.

More Related Videos

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Published on: November 8, 2011

Related Experiment Videos

Last Updated: Apr 22, 2026

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Published on: July 24, 2016

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Published on: November 8, 2011

Area of Science:

Pediatric Neurology
Infectious Diseases
Virology

Background:

Epstein-Barr virus (EBV) causes diverse human illnesses, from mononucleosis to certain cancers.
EBV infections of the central nervous system are uncommon, particularly in infants.

Purpose of the Study:

To describe the clinical presentation and diagnostic course of an unusual case of EBV encephalitis in a 10-month-old infant.
To correlate clinical findings with serologic studies and cerebrospinal fluid (CSF) EBV DNA dynamics.

Main Methods:

Case report detailing clinical manifestations, neurological symptoms (febrile infection, seizures), and diagnostic workup.
Serologic testing for EBV antibodies.
Analysis of EBV DNA levels in cerebrospinal fluid over time.

Main Results:

The infant presented with fever and seizures, indicative of central nervous system involvement.
Serological studies confirmed EBV infection.
Dynamic changes in EBV DNA levels within the CSF were observed.
Spontaneous clinical recovery occurred.

Conclusions:

EBV can cause encephalitis in infants, presenting with non-specific febrile illness and seizures.
Monitoring EBV DNA in CSF is crucial for diagnosing and managing EBV nervous system infections.
Prompt diagnosis and supportive care can lead to favorable outcomes, even in young children.