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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Types of RNA01:20

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Types of RNA01:23

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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The many faces of long noncoding RNAs.

Alessandro Gardini1, Ramin Shiekhattar

  • 1Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, FL, USA.

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Long noncoding RNAs (ncRNAs) are key transcriptional products in cells. This review explores their biogenesis, function, and role as chromatin regulators, highlighting future research directions in this growing field.

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eRNAsenhancerlncRNAsnoncodingtranscription

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Area of Science:

  • Genomics
  • Molecular Biology
  • Biochemistry

Background:

  • The study of noncoding RNAs has rapidly expanded, moving from a specialized area to a central part of modern biology.
  • Genomic technologies offer a deeper understanding of the mammalian genome, revealing extensive non-protein-coding regions.
  • Evidence indicates that noncoding RNAs constitute a significant portion of cellular transcriptional output.

Purpose of the Study:

  • To review the biogenesis and functions of long noncoding RNAs (lncRNAs).
  • To discuss the established roles of lncRNAs as critical regulators of chromatin.
  • To explore emerging areas and future research avenues in the field of lncRNAs.

Main Methods:

  • Literature review of recent advancements in noncoding RNA research.
  • Analysis of genomic data and functional studies related to lncRNAs.
  • Synthesis of current knowledge on lncRNA biogenesis, function, and chromatin interactions.

Main Results:

  • Long noncoding RNAs are abundant transcriptional products with diverse cellular roles.
  • lncRNAs play significant roles in modulating chromatin structure and function.
  • The field is rapidly evolving, with new discoveries continually emerging.

Conclusions:

  • Long noncoding RNAs are integral components of cellular function and regulation.
  • Further research into lncRNA mechanisms will uncover new biological insights and therapeutic potentials.
  • Understanding lncRNAs is crucial for advancing fields like genomics, epigenetics, and developmental biology.