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Related Concept Videos

Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show...
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Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and...
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The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
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Dementia l: Introduction01:22

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Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
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Alzheimer Disease l: Introduction01:29

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Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Related Experiment Video

Updated: Apr 22, 2026

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
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Destination and source memory in Huntington's disease.

Mohamad El Haj1, Marie Caillaud2, Christophe Verny3,4

  • 1Research Unit on Cognitive and Affective Sciences, Department of Psychology, University of North of France, Lille, France.

Journal of Neuropsychology
|October 11, 2014
PubMed
Summary
This summary is machine-generated.

Huntington's disease (HD) patients exhibit deficits in both destination memory and source memory. Destination memory impairment in HD is linked to their overall episodic memory performance.

Keywords:
Huntington's diseasedestination memoryepisodic memoryexecutive functionsource memory

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Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neurology

Background:

  • Destination memory involves recalling where information was sent, while source memory concerns recalling where it originated.
  • Huntington's disease (HD) is a neurodegenerative disorder affecting cognitive functions, including memory.

Purpose of the Study:

  • To compare destination and source memory abilities in individuals with Huntington's disease (HD) against healthy adults.
  • To investigate the relationship between destination memory and episodic memory in HD patients.

Main Methods:

  • Participants (HD patients and healthy adults) performed destination and source memory tasks involving placing and retrieving items from colored boxes.
  • Memory recall was assessed by asking participants to identify the correct box for item deposition (destination) and extraction (source).

Main Results:

  • HD participants demonstrated significantly lower performance in both destination and source memory recall compared to healthy controls.
  • Destination recall performance in HD patients was found to be significantly correlated with their episodic memory recall.

Conclusions:

  • Individuals with Huntington's disease exhibit impairments in both destination and source memory.
  • Episodic memory deficits appear to significantly contribute to destination memory difficulties observed in Huntington's disease.