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Related Experiment Videos

Necessity for routine obstetric screening for hepatitis B surface antigen.

J S Greenspoon1, J Martin, R L Greenspoon

  • 1Department of Obstetrics and Gynecology, University of Southern California, Los Angeles County Medical Center.

The Journal of Reproductive Medicine
|September 1, 1989
PubMed
Summary

Routine screening for hepatitis B surface antigen (HBSAg) in pregnant women is crucial. This identifies mothers who can transmit hepatitis B virus to infants, enabling timely immunoprophylaxis to prevent infection.

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Area of Science:

  • Hepatology
  • Public Health
  • Obstetrics

Background:

  • Hepatitis B virus (HBV) poses a significant risk for perinatal transmission.
  • Current risk factor-based screening for hepatitis B surface antigen (HBSAg) in pregnant women is insufficient.

Purpose of the Study:

  • To evaluate the prevalence of HBSAg in pregnant women at Los Angeles County Medical Center.
  • To determine the necessity of universal HBSAg screening in obstetric populations.
  • To assess the cost-effectiveness of preventing perinatal HBV transmission.

Main Methods:

  • Serologic testing for HBSAg was performed on 2,000 pregnant women.
  • Demographic data and risk factors were collected.
  • Literature review of obstetric surveys on HBV screening and immunoprophylaxis.

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Main Results:

  • 8 out of 2,000 pregnant women tested positive for HBSAg (0.4% prevalence).
  • Only 2 of the 8 HBSAg-positive women met the Centers for Disease Control's defined risk factors.
  • Existing literature supports universal screening and infant immunoprophylaxis.

Conclusions:

  • Universal HBSAg screening of pregnant women is necessary to identify all carriers.
  • Implementing universal screening and infant immunoprophylaxis is essential to prevent perinatal HBV transmission.
  • This screening policy is a cost-effective public health measure.