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Patterns of antibacterials use in intensive care units
Edilson Floriano Dos Santos1, Liana Lauria-Pires2
1Escola Superior de Ciências da Saúde, Fundação de Ensino e Pesquisa em Ciências da Saúde, Brasília, DF, Brasil.
Revista Brasileira De Terapia Intensiva
|October 11, 2014
Summary
Antimicrobial use patterns in intensive care units (ICUs) varied, with private hospitals showing higher consumption than public ones. Despite differences in overall use, common antibiotic classes like cephalosporins and penicillins were prevalent across all ICUs studied.
Area of Science:
- Pharmacology
- Infectious Diseases
- Critical Care Medicine
Background:
- Antimicrobial stewardship is crucial in intensive care units (ICUs) to combat resistance.
- Understanding regional variations in antimicrobial prescribing is essential for targeted interventions.
Purpose of the Study:
- To compare antimicrobial prescribing patterns in public versus private hospital ICUs.
- To analyze antimicrobial consumption using the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) system.
Main Methods:
- A prospective cohort study was conducted in three ICUs (two public, one private).
- Antimicrobial use was quantified using the ATC/DDD system, calculating consumption density (DDD1000).
Main Results:
- Overall consumption density was 1,689.0 DDD1000.
- The private hospital ICU exhibited significantly higher antimicrobial consumption (2,191.7 DDD1000) compared to public ICUs (1,499.5 DDD1000).
- Third-generation cephalosporins, penicillins/beta-lactamase inhibitors, carbapenems, and fluoroquinolones were the most frequently used antibiotic classes.
Conclusions:
- Antimicrobial prescribing patterns were not uniform across the studied ICUs.
- Significant differences in consumption volume were observed between private and public hospital ICUs.
- Despite consumption disparities, the most utilized antibiotic classes remained consistent across all ICUs.
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