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Updated: Apr 22, 2026
05:07
Multimodality Diagnosis of Mesenteric Ischemia
Published on: July 21, 2023
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Olmesartan-related sprue-like enteropathy
Naresh Bhat1, N K Anupama, Amit Yelsangikar
1Department of Gastroenterology, Columbia Asia Referral Hospital, 26/1, Brigade Gateway, Malleswaram West, Yeshwanthpur, Bangalore, 560 055, India, nareshbhat56@gmail.com.
Summary
Chronic diarrhea can be difficult to diagnose. This study highlights olmesartan-induced sprue-like enteropathy as a cause of persistent diarrhea, often overlooked in clinical evaluations.
Area of Science:
- Gastroenterology
- Pharmacology
- Pathology
Background:
- Chronic diarrhea presents a diagnostic challenge in clinical practice.
- Villous atrophy, a common finding, has a broad differential diagnosis.
- Drug-induced diarrhea is frequently overlooked during patient evaluations.
Observation:
- This study focuses on challenging cases of small bowel diarrhea.
- The cases presented involve a specific drug-induced enteropathy.
Findings:
- Olmesartan-mediated enteropathy can mimic celiac disease.
- Villous atrophy in these patients is secondary to olmesartan use.
- This condition represents a specific cause of drug-induced chronic diarrhea.
Implications:
- Clinicians should consider olmesartan-induced sprue-like enteropathy in patients with unexplained chronic diarrhea and villous atrophy.
- Early recognition can prevent unnecessary investigations and guide appropriate management.
- This highlights the importance of a thorough medication history in diagnosing gastrointestinal disorders.
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