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Rate-control drug delivery systems: controlled release vs. sustained release.

Y W Chien1

  • 1Controlled Drug-Delivery Research Center, Rutgers University, College of Pharmacy, Piscataway, New Jersey 08855-0789.

Medical Progress Through Technology
|January 1, 1989
PubMed
Summary

New drug delivery systems offer controlled release, sustained efficacy, and targeted delivery. These advanced systems are categorized into pre-programmed, activation-controlled, and feedback-regulated types for improved biomedical applications.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Pharmacology

Background:

  • Recent technical advancements have led to sophisticated drug delivery systems.
  • These systems aim to control drug release rates, prolong therapeutic effects, and enable targeted delivery.

Purpose of the Study:

  • To classify new generation drug delivery systems based on technical sophistication.
  • To analyze the fundamentals and biomedical applications of rate-controlled drug delivery systems.
  • To provide a foundation for future innovative drug delivery system development.

Main Methods:

  • Categorization of drug delivery systems into three types: pre-programmed, activation-controlled, and feedback-regulated.
  • Analysis of the underlying science and technology for each category.

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  • Review of marketed and developing drug delivery devices and their applications.

    • Main Results:

    • Identification of three major categories of rate-control drug delivery systems.
    • Examples of successful biomedical applications for each system type.
    • Understanding of the science and technology enabling these advancements.

    Conclusions:

    • The development of advanced drug delivery systems is progressing rapidly.
    • Classification provides a framework for understanding current technologies.
    • Further innovation is expected, building on current scientific and technological foundations.