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Psoriasis and ischemic coronary artery disease
L Mahiques-Santos1, C J Soriano-Navarro2, G Perez-Pastor1
1Servicio de Dermatología, Hospital La Plana, Villa Real, Castellón, España.
Actas Dermo-Sifiliograficas
|October 12, 2014
Summary
Psoriasis patients show a higher risk of ischemic coronary artery disease (CAD). This study confirms an independent association between psoriasis and CAD in a Mediterranean population, highlighting a significant public health concern.
Area of Science:
- Cardiology
- Dermatology
- Epidemiology
Background:
- Psoriasis is a chronic inflammatory condition linked to increased risk of ischemic coronary artery disease (CAD) in certain populations.
- Understanding this association is crucial for cardiovascular risk assessment in psoriasis patients.
Purpose of the Study:
- To investigate the association between psoriasis and ischemic coronary artery disease (CAD) within a specific geographic region (Castellón, Spain).
- To determine if psoriasis is an independent risk factor for CAD after accounting for other cardiovascular risk factors.
Main Methods:
- A cross-sectional study utilized patient records from 2005-2012.
- Compared 9,181 patients with psoriasis against 21,925 patients with melanocytic nevus (control group).
- Analyzed the prevalence of CAD and cardiovascular risk factors (hypertension, diabetes, dyslipidemia, obesity) in both groups.
Main Results:
- Univariate analysis revealed significant associations between CAD and psoriasis, age, sex, hypertension, diabetes mellitus, dyslipidemia, and obesity.
- Multivariate regression analysis, after adjusting for age, sex, and other risk factors, confirmed that psoriasis is independently associated with CAD (P<.029).
Conclusions:
- The study supports the hypothesis that patients in this Mediterranean population with psoriasis have an elevated risk of ischemic CAD.
- Findings emphasize the importance of considering cardiovascular risk in the management of psoriasis.
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