Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

327
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
327
Biological Effects of Radiation02:59

Biological Effects of Radiation

15.3K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
15.3K
Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis00:59

Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis

422
Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
422
Model Approaches for Pharmacokinetic Data: Compartment Models01:14

Model Approaches for Pharmacokinetic Data: Compartment Models

863
Compartmental analysis is a widely adopted approach to characterizing drug pharmacokinetics. It uses compartment models that conceptualize the body as a collection of reversibly communicating compartments, each representing a group of tissues exhibiting similar drug distribution characteristics. The movement rate of the drug between these compartments is typically described by first-order kinetics.
Two primary types of compartment models are recognized: mammillary and catenary. The more...
863
Dose-Response Relationship: Overview01:03

Dose-Response Relationship: Overview

5.0K
Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
5.0K
Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

976
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
976

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of experimental values of effective energies and beam quality correction factors for out-of-field dosimetry in external beam radiotherapy using radiophotoluminescent glass dosimeters.

Biomedical physics & engineering express·2026
Same author

Metabolic determinants of cancer immunotherapy outcomes identified by plasma profiling.

Nature medicine·2026
Same author

Enhancing heart and lung dose reconstruction in breast cancer radiotherapy using publicly available out-of-field dose profiles.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026
Same author

Redefining radiotherapy: the gut as an active target in Immuno-Oncology.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Single cells and spatial RNA profiling reveal that inflammatory fibroblasts arise from Edil3 stromal cells in the colon after irradiation.

Cell death and differentiation·2026
Same author

New Paradigms in Theranostics of Prostate Cancer: The Rise of α-Emitters and Next-generation Targets.

European urology focus·2026

Related Experiment Video

Updated: Apr 22, 2026

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
10:23

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

Published on: December 1, 2023

1.3K

Functional data analysis in NTCP modeling: a new method to explore the radiation dose-volume effects.

Mohamed Amine Benadjaoud1, Pierre Blanchard2, Boris Schwartz1

  • 1Center for Research in Epidemiology and Population Health (CESP) INSERM 1018 Radiation, Epidemiology Group, Villejuif, France; Université Paris sud, Le Kremlin-Bicêtre, France; Institut Gustave Roussy, Villejuif, France.

International Journal of Radiation Oncology, Biology, Physics
|October 12, 2014
PubMed
Summary

Functional data analysis offers a flexible approach to understanding radiation dose-volume effects on normal tissues. This method improves normal tissue complication probability modeling for rectal bleeding after prostate radiation therapy.

More Related Videos

Effective Analysis of Human Exposure Conditions with Body-worn Dosimeters in the 2.4 GHz Band
06:43

Effective Analysis of Human Exposure Conditions with Body-worn Dosimeters in the 2.4 GHz Band

Published on: May 2, 2018

9.7K
Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.4K

Related Experiment Videos

Last Updated: Apr 22, 2026

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
10:23

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

Published on: December 1, 2023

1.3K
Effective Analysis of Human Exposure Conditions with Body-worn Dosimeters in the 2.4 GHz Band
06:43

Effective Analysis of Human Exposure Conditions with Body-worn Dosimeters in the 2.4 GHz Band

Published on: May 2, 2018

9.7K
Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.4K

Area of Science:

  • Radiation Oncology
  • Medical Physics
  • Biostatistics

Background:

  • Understanding radiation dose-volume effects is crucial for minimizing normal tissue complications in external beam radiation therapy.
  • Accurate modeling of normal tissue complication probability (NTCP) is essential for optimizing treatment plans.
  • Rectal bleeding (RB) is a common complication following prostate radiation therapy, necessitating effective predictive models.

Purpose of the Study:

  • To introduce and evaluate a novel functional data analysis (FDA) method for exploring radiation dose-volume effects.
  • To apply FDA to normal tissue complication probability (NTCP) modeling for rectal bleeding (RB) in patients undergoing prostate radiation therapy.
  • To compare the performance of the FDA method against traditional NTCP models.

Main Methods:

  • Kernel density estimation was used to derive probability density functions from 141 rectum differential dose-volume histograms.
  • Functional principal component analysis (FPCA) explored variation modes in dose distributions.
  • Functional logistic regression (FLR) assessed the association between functional principal components and RB, comparing it with Lyman-Kutcher-Burman, standard logistic regression (LM), and multivariate PCA models.

Main Results:

  • The incidence of grade ≥2 RB was 14%.
  • FPCA and FLR identified interdependence between intermediate/high dose volumes and complications as highly correlated.
  • The FLR method enhanced understanding of the volume effect by incorporating treatment specificity.
  • Advanced age was a significant risk factor for RB (OR=1.123), improving model fits when included.

Conclusions:

  • Functional data analysis presents an attractive and flexible method for estimating dose-volume effects in normal tissues.
  • The FDA approach offers a more nuanced understanding of the relationship between radiation dose distribution and normal tissue complications.
  • Incorporating clinical factors like age can further improve the accuracy of NTCP models.