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Uterine Tubes

Uterine Tubes

The uterine or fallopian tubes function as the conduit through which oocytes travel from the ovaries to the uterus. Each fallopian tube measures approximately 10 to 13 cm long and is anatomically divided into the infundibulum, ampulla, isthmus, and interstitial part (or intramural segment). The infundibulum is characterized by its funnel shape and features extensions called fimbriae which reach towards the peritoneal cavity. These fimbriae play a critical role during ovulation as they extend...

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Related Experiment Video

Updated: Apr 22, 2026

An Efficient Method for Extracting Human Fallopian Tube Epithelia for Single-cell Analyses

An Efficient Method for Extracting Human Fallopian Tube Epithelia for Single-cell Analyses

Published on: March 28, 2025

Identification of putative fallopian tube stem cells.

Victoria Snegovskikh¹, Levent Mutlu², Effi Massasa²

¹Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University, New Haven, CT, USA Department of Obstetrics and Gynecology, Warren Alpert Medical School of Brown University, Providence, RI, USA.

Reproductive Sciences (Thousand Oaks, Calif.)

|October 12, 2014

Summary

The oviduct contains stem cells that aid in tissue repair and regeneration. These progenitor cells may be crucial for tubal health, with deficiencies potentially linked to diseases like hydrosalpinx and ectopic pregnancy.

Keywords:

ectopic pregnancy fallopian tube hydrosalpinx infertility ovarian cancer oviduct reproduction reproductive tract stem cell

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Ex Vivo Culture of Primary Human Fallopian Tube Epithelial Cells

Ex Vivo Culture of Primary Human Fallopian Tube Epithelial Cells

Published on: May 9, 2011

Area of Science:

Reproductive Biology
Stem Cell Research
Histology

Background:

Stem cells are vital for tissue repair and regeneration in adults.
Previous research established stem cells' role in endometrial repair.
The oviduct's potential stem cell population for tissue maintenance was unexplored.

Purpose of the Study:

To identify and characterize stem/progenitor cells within the murine oviduct.
To investigate the potential role of these cells in oviduct maintenance and regeneration.

Main Methods:

Label-retaining cells (LRCs) were identified using 5-bromo-2-deoxyuridine (BrdU) labeling in young mice.
Immunofluorescence and confocal microscopy were employed to visualize BrdU-positive cells in oviduct sections.
Oviduct morphology was confirmed using hematoxylin and eosin staining.

Main Results:

A population of label-retaining cells (LRCs), indicative of stem/progenitor cells, was identified in the murine oviduct.
These LRCs were located at the base of oviduct villi, suggesting a stem cell niche.
LRCs constituted approximately 0.5% of all nucleated cells in the oviduct.

Conclusions:

The oviduct harbors a population of progenitor cells essential for its repair and regeneration.
A deficit in oviduct stem cell reserves may contribute to tubal pathologies such as hydrosalpinx and ectopic pregnancy.