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Updated: Apr 22, 2026
Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
Published on: July 28, 2023
Differential susceptible loci expression in keloid and hypertrophic scars in the Chinese Han population
Guodong Teng1, Chang Liu, Minliang Chen
1From the *Institute of Plastic Surgery, XiJing Hospital, the Fourth Military Medical University, Xi'an, Shanxi; †Medical School of Chinese PLA, Beijing; and ‡Department of Burn and Plastic Surgery, and §Wound Healing and Cell Biology Laboratory, Burns Institute, the First Affiliated Hospital of Chinese PLA General Hospital, Beijing, People's Republic of China.
Background:
Hypertrophic scars (HSs) and keloids (KDs) are commonly seen as 2 different diseases. We aimed to find potential genes associated with KD and HS formation.
Methods:
We selected 4 single-nucleotide polymorphisms (SNPs) (based on the whole genome resequencing we have done) for replication in 71 KDs and 50 HSs using the Sequenom Massarray system.
Results:
We found evidence of significant association at rs181924090, P = 0.0075; rs183178644, P = 0.0151; and rs151091483, P = 0.0073. However, at rs141156594, there was no significant association between KD and HS (P = 0.7893).
Conclusions:
rs181924090 (11p15.5, SIRT3), rs151091483 (17p13.1, MYH8), and rs183178644 (6p25.3, HUS1B) are new potential SNPs associated with KD formation, especially closely related to tumor behaviors as KD is, whereas rs141156594 (18q22.2, RTTN) is a new SNP involved in the extracellular matrix formation in wound healing.
