Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

50
Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
50
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.9K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.9K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

2.3K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
2.3K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

15.4K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
15.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lipophilic Prodrug of Methotrexate in the Membrane of Liposomes Promotes Their Uptake by Human Blood Phagocytes.

Acta naturae·2020
Same author

IFN-α, IFN-β, and IFN-γ Have Different Effect on the Production of Proinflammatory Factors Deposited in Weibel-Palade Bodies of Endothelial Cells Infected with Herpes Simplex Virus Type 1.

Bulletin of experimental biology and medicine·2016
Same author

Effects of gold nanoparticles on erythrocyte hemolysis.

Bulletin of experimental biology and medicine·2014
Same author

Effect of type 1 herpes simplex infection of phenotypic peculiarities of human vascular endothelial cells in culture.

Bulletin of experimental biology and medicine·2013
Same author

[Adhesion molecules expressed in vascular endothelial cells in natural immunity against viral infections].

Vestnik Rossiiskoi akademii meditsinskikh nauk·2011
Same author

[Changing the protective properties of the receptor domain of protective antigen anthrax exotoxin, depending on the orientation of the presentation on nanoparticles].

Bioorganicheskaia khimiia·2011

Related Experiment Video

Updated: Apr 22, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
08:32

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

9.7K

[Human interferon modulates infected vascular endothelium function].

O N Shcheglovitova, N N Skliankina, N V Boldyreva

    Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
    |October 14, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Interferons (IFN) alpha, beta, and gamma modulate inflammatory responses in Herpes simplex virus type 1 (HSV-1) infected endothelial cells. The type of interferon influences the production of cytokines and other mediators, impacting innate immunity.

    More Related Videos

    High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
    10:00

    High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

    Published on: March 24, 2015

    13.6K
    Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
    07:56

    Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis

    Published on: May 5, 2023

    964

    Related Experiment Videos

    Last Updated: Apr 22, 2026

    Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
    08:32

    Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

    Published on: March 2, 2014

    9.7K
    High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
    10:00

    High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes

    Published on: March 24, 2015

    13.6K
    Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
    07:56

    Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis

    Published on: May 5, 2023

    964

    Area of Science:

    • Immunology
    • Virology
    • Cell Biology

    Context:

    • Endothelial cells play a crucial role in inflammation.
    • Herpes simplex virus type 1 (HSV-1) infection can affect endothelial cell function.
    • Interferons (IFNs) are key modulators of the immune response.

    Purpose:

    • To investigate the impact of IFN-alpha, IFN-beta, and IFN-gamma on HSV-1 infected endothelial cells.
    • To assess how different IFNs modulate the production of inflammatory mediators.
    • To understand the role of IFNs in innate immunity during viral infections.

    Summary:

    • All tested interferons (IFN-alpha, IFN-beta, IFN-gamma) stimulated Interleukin-6 (IL-6) production.
    • IFN-alpha and IFN-beta increased Interleukin-8 (IL-8) production, while IFN-gamma inhibited it.
    • IFN-alpha and IFN-gamma increased nitric oxide synthesis and decreased endothelin-1, whereas IFN-beta increased endothelin-1.

    Impact:

    • HSV-1 infection does not impair the ability of IFNs to modulate inflammatory responses in endothelial cells.
    • Exogenous IFNs modulate innate immunity in both intact and HSV-1 infected vascular endothelium.
    • The specific type of interferon determines the nature of this modulation, highlighting differential therapeutic potential.