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[Cardiorespiratory repercussions of the peritoneal dialysis in critically ill children]
Patrícia Gombai Barcellos1, Cíntia Johnston2, Werther Brunow de Carvalho3
1EPM, UNIFESP.
Insights
Peritoneal dialysis (PD) in critically ill children can cause cardiorespiratory changes, including altered pulmonary function and hemodynamics. Close monitoring during and after PD is crucial to prevent clinical deterioration in pediatric patients with acute renal failure.
Area of Science:
- Pediatric Nephrology
- Critical Care Medicine
- Cardiopulmonary Physiology
Context:
- Peritoneal dialysis (PD) is a vital renal replacement therapy for critically ill children with acute renal failure.
- While effective, PD can induce significant cardiorespiratory alterations in this vulnerable population.
- Understanding these repercussions is essential for safe and effective patient management.
Purpose:
- To systematically review the cardiorespiratory effects of PD in pediatric patients.
- To assess the evidence level of studies examining these effects.
- To provide a comprehensive overview of PD-induced cardiorespiratory changes in critically ill children.
Summary:
- A review of 13 articles (evaluating 178 pediatric patients) identified frequent respiratory complications including decreased pulmonary compliance and oxygenation, and increased airway resistance.
- Cardiovascular changes observed during PD encompass increased mean arterial pressure, pulmonary artery pressures, and systemic vascular resistance, alongside decreased central venous pressure.
- Post-infusion findings indicated improved oxygenation and reduced alveolar-arterial differences.
Impact:
- Highlights the significant cardiorespiratory impact of PD in critically ill children.
- Emphasizes the necessity for vigilant monitoring of pulmonary and cardiovascular parameters during and after PD.
- Informs multidisciplinary teams to optimize care and prevent adverse events in pediatric patients undergoing PD for acute renal failure.
Background And Objectives:
Peritoneal dialysis (PD) is frequently used to replace glomerular filtration and to control acid-base, electrolyte and fluid disturbances in critically ill children with acute renal failure. However, cardiorespiratory changes can happen during this procedure. The objective of this review is to describe the PD cardio-respiratory repercutions in the pediatric patient and the evidence level of the studies that approach these repercutions.
Methods:
Bibliographic revision about PD cardio-respiratory repercutions in the pediatric patient. Medline, Ovid e Lilacs databases were searched for articles from 1990 to 2007 with the following key words in Portuguese, English and Spanish: diálise peritoneal, efeitos hemodinâmicos, complicações respiratórias, complicações cardíacas, Pediatria; peritoneal dialysis, hemodynamic effects, respiratory complications, cardiac complications, Pediatric; peritoneal diálisis, efecto hemodinámico, complicaciones respiratorias, complicaciones cardiacas, Pediatria. The retrieved articles were classified according to Cook et al. 1992.
Results:
Thirteen articles were retrieved, 8 of them were about cardiorespiratory repercussions and five approached respiratory repercussions of PD. These studies evaluated 178 critically ill patients, from newborns to adolescents. Among the respiratory repercutions during PD the most frequent ones were decrease of the pulmonary compliance and arterial oxygen partial pressure and increase of airway resistance and carbon dioxide partial pressure; after the infusion of PD fluid the studies pointed out an increased arterial oxygen partial pressure/ inspired oxygen fraction relation and diminution of the alveolar-arterial difference and oxygenation index. Increase of the mean arterial pressure, pulmonary artery pressure, right and left atrial pressure and systemic vascular resistance and, reduction of the central venous pressure were the described cardio-circulatory repercutions during PD.
Conclusions:
Pulmonary volumes, gas exchange and cardio-circulatory alterations are the most frequent complications during and after PD in the pediatric patient. Therefore critically ill pediatric patients with acute renal failure needing PD should be monitored during and after this procedure to avoid clinical deterioration and to educate the multi-professional team.
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