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Updated: Apr 22, 2026
Experimental Protocol to Investigate Particle Aerosolization of a Product Under Abrasion and Under Environmental Weathering
Published on: September 16, 2016
Interactions between mammalian cells and nano- or micro-sized wear particles: physico-chemical views against
1School of Pharmacy and Pharmaceutical Science, Cardiff University, Cardiff, UK; School of Engineering, Cardiff University, Cardiff, UK; Department of Biological Engineering, MA Institute of Technology, Cambridge, USA.
Abstract:
Total joint arthroplasty (TJA) is a more and more frequent approach for the treatment of end-stage osteoarthritis in young and active adults; it successfully relieves joint pain and improves function significantly enhancing the health-related quality of life. Aseptic loosening and other wear-related complications are some of the most recurrent reasons for revision of TJA. This review focuses on current understanding of the biological reactions to prosthetic wear debris comparing in vivo and in vitro results. Mechanisms of interactions of various types of cells with metal, polymeric and ceramic wear particles are summarised. Alternative views based on multidisciplinary approaches are proposed to consider physico-chemical, surface parameters of wear particles (such as: particle size, geometry and charge) and material (particle chemical composition and its nature) with biological effects (cellular responses).
