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Predictors of hospital outcome in patients with cerebral venous thrombosis

Pat Korathanakhun1, Pornchai Sathirapanya1, Sarayut Lucien Geater1

  • 1Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|October 14, 2014
PubMed

Insights

Focal neurologic deficits and severe disability on admission predict poor outcomes in Thai cerebral venous thrombosis (CVT) patients. However, seizures may indicate a lower risk of dependency or death in CVT cases.

Area of Science:

  • Neurology
  • Vascular Neurology
  • Epidemiology

Background:

  • Cerebral venous thrombosis (CVT) studies in Thailand are limited.
  • Understanding CVT's clinical features, risk factors, and outcomes in Thai populations is crucial.

Purpose of the Study:

  • To identify predictors of hospital outcomes in Thai patients diagnosed with CVT.
  • To analyze factors influencing dependency or death post-CVT.

Main Methods:

  • Retrospective study of 90 CVT patients at Songklanagarind Hospital (2002-2013).
  • Data collected included demographics, clinical presentations, associated factors, neuroimaging, treatment, and outcomes.
  • Univariate and multivariate logistic regression analyzed outcome predictors.

Main Results:

  • Common presentations: focal neurologic deficits (36.7%), seizures (33.3%), cavernous sinus syndrome (32.2%).
  • Associated conditions: infections (30.0%), cancer (11.1%). Intracranial hemorrhage occurred in 36.7%.
  • 52.2% had poor outcomes (mRS 3-6). Independent predictors of poor outcomes were focal neurologic deficit (OR 14.26) and admission mRS 3-5 (OR 35.26). Seizures predicted better outcomes (OR 0.19).

Conclusions:

  • Focal neurologic deficit and severe disability at admission are key predictors of poor outcomes in Thai CVT patients.
  • Seizures may be associated with a lower incidence of dependency or death.
  • Thai CVT patients exhibit a higher prevalence of cavernous sinus syndrome and sinonasal/intracranial infections.
Abstract

Keywords:
Cerebral venous thrombosisThai peoplecavernous sinus syndromehospital outcomepredictorsrhinosinal infection

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