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Biomarkers for diagnosis and prognostic stratification of aortic dissection: challenges and perspectives

Fulvio Morello1, Pavel Piler, Miroslav Novak

  • 1Emergency Department, A.O. Città della Salute e della Scienza, Molinette Hospital, Turin, Italy.

Biomarkers in Medicine
|October 14, 2014
PubMed

Insights

Circulating biomarkers show promise for diagnosing aortic dissection (AD), a serious vascular condition. These markers could aid in screening, risk identification, and prognosis, potentially improving patient outcomes.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Discovery
  • Vascular Surgery

Background:

  • Aortic dissection (AD) is a life-threatening vascular emergency.
  • Current AD diagnosis relies heavily on clinical judgment and urgent imaging.
  • There is a need for improved diagnostic and prognostic tools for AD.

Purpose of the Study:

  • To review current data on circulating biomarkers for aortic dissection.
  • To discuss the potential of these biomarkers in AD diagnosis and risk stratification.
  • To explore future perspectives for biomarker-based AD management.

Main Methods:

  • Literature review of studies identifying potential AD biomarkers.
  • Analysis of biomarkers from extracellular matrix, vascular smooth muscle cells, coagulation, and inflammation.
  • Discussion of biomarker utility in screening, diagnosis, and prognosis.

Main Results:

  • Several potential biomarkers have been identified in patients with AD.
  • These include markers related to extracellular matrix, smooth muscle cells, coagulation, and inflammation.
  • Elevated circulating levels of these biomarkers are observed in AD patients.

Conclusions:

  • Circulating biomarkers hold significant potential for AD diagnosis and prognostic stratification.
  • Biomarkers could aid in screening, ruling out AD, and identifying high-risk patients.
  • Further research is needed to validate and implement these biomarkers in clinical practice.

Keywords:
C-reactive proteinaortic dissectionbiomarkercalponin creatinine kinased-dimerdiagnosiselastinmatrix metalloproteinasemyosinplatelets

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