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Biomarkers in congenital heart disease

Richard Dobson1, Hamish A Walker, Niki L Walker

  • 1Scottish Adult Congenital Cardiac Service, West of Scotland Heart & Lung Centre, Golden Jubilee National Hospital, Clydebank, G81 4DY, UK.

Biomarkers in Medicine
|October 14, 2014
PubMed

Insights

Adults with congenital heart disease (CHD) now outnumber children with CHD. While technology aids anatomical assessment, the role of cardiac biomarkers for managing chronic heart failure in adult CHD requires further evaluation.

Area of Science:

  • Cardiology
  • Adult Congenital Heart Disease (ACHD)

Background:

  • The population of adults with congenital heart disease (CHD) now exceeds that of children with CHD.
  • Long-term management necessitates sequential assessment of anatomy, physiology, and symptoms for intervention decisions.
  • Technological advancements have significantly improved anatomical and functional assessments.

Purpose of the Study:

  • To evaluate the current role and potential utility of cardiac biomarkers in the assessment and management of adult patients with congenital heart disease.
  • To compare the application of cardiac biomarkers in adult CHD with their established use in acquired heart disease.

Main Methods:

  • Review of current literature on adult congenital heart disease management.
  • Analysis of the application and validation of cardiac biomarkers in acquired heart failure.
  • Assessment of ongoing studies and challenges in applying cardiac biomarkers to adult CHD.

Main Results:

  • Technological advancements have enhanced the assessment of anatomy and cardiac function in adult CHD.
  • Cardiac biomarkers have revolutionized chronic heart failure assessment in acquired heart disease.
  • The utility of cardiac biomarkers for chronic heart failure assessment in adult CHD is still under investigation and requires further validation.

Conclusions:

  • Effective management of adult CHD relies on integrated assessment of anatomy, physiology, and symptoms.
  • While cardiac biomarkers are crucial in acquired heart failure, their specific role in adult CHD management is not yet fully established.
  • Further research is needed to determine the precise value and application of cardiac biomarkers in the long-term care of adults with congenital heart disease.

Keywords:
adult congenital heart diseasebiomarkersheart failureheart function

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