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Related Concept Videos

What is Metabolism?00:52

What is Metabolism?

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Overview
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Introduction to Metabolism01:30

Introduction to Metabolism

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Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...
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Overview of Metabolism01:40

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Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
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Regulation of Metabolism01:19

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Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
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Metabolic Rate01:25

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The human body is a powerhouse of energy, with every cell performing numerous functions that require energy. This energy production and consumption is measured by the metabolic rate, which quantifies the total heat generated by all the body's chemical reactions and mechanical work. This measurement helps to determine the rate of kilocalorie (kcal) consumption needed to fuel all ongoing activities.
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Metabolism of Chemolithotrophs01:15

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Chemolithotrophs are microorganisms that obtain energy by oxidizing inorganic molecules such as hydrogen gas (H₂), ammonia (NH₃), reduced sulfur compounds (H₂S, S²⁻), and ferrous iron (Fe²⁺). Unlike heterotrophic organisms that rely on organic carbon, chemolithotrophs transfer electrons from these inorganic donors to the electron transport chain (ETC), generating a proton motive force (PMF) that drives ATP synthesis through oxidative phosphorylation.
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Updated: Apr 22, 2026

A Method for Measuring Metabolism in Sorted Subpopulations of Complex Cell Communities Using Stable Isotope Tracing
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Metabolism.

Martin H Plawecki1, David W Crabb2

  • 1Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.

Handbook of Clinical Neurology
|October 14, 2014
PubMed
Summary
This summary is machine-generated.

Individual differences in how the body processes ethanol, or alcohol, are significant. Pharmacokinetic modeling helps understand these variations and their link to alcohol use disorders.

Keywords:
alcohol dehydrogenasealdehyde dehydrogenasecytochrome P450 2E1ethanolpharmacokinetics

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Genetics

Background:

  • Ethanol (alcohol) metabolism involves well-characterized enzymes and pathways.
  • Genetic variations in metabolic enzymes influence alcoholism risk and ethanol pharmacokinetics.
  • Individual responses to ethanol show significant variability despite straightforward absorption and distribution.

Purpose of the Study:

  • To review ethanol metabolism.
  • To emphasize the utility of pharmacokinetic modeling in understanding ethanol handling.
  • To highlight the role of pharmacokinetic modeling in studying ethanol effects.

Main Methods:

  • Review of existing literature on ethanol metabolism and pharmacokinetics.
  • Analysis of the impact of genetic variants on ethanol processing.
  • Application of pharmacokinetic modeling to understand inter-individual variability.

Main Results:

  • Substantial variability exists in blood alcohol levels after standard ethanol doses.
  • These pharmacokinetic differences likely contribute to varied responses to ethanol.
  • Variability may influence nervous system effects and risk for ethanol use disorders.

Conclusions:

  • Understanding ethanol pharmacokinetics is crucial for interpreting research on its effects.
  • Pharmacokinetic modeling provides valuable insights into individual ethanol processing.
  • Further study of pharmacokinetic variability is essential for understanding ethanol use disorders.