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Lanreotide autogel in acromegaly - a decade on
Nikolaos Kyriakakis1, Vincent Chau, Julie Lynch
1St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds Centre for Diabetes and Endocrinology, Department of Endocrinology , Beckett Street, Leeds LS9 7TF , UK +44 0 113 206 4578 ; +44 0 113 206 5065 ; robert.murray@leedsth.nhs.uk.
Lanreotide autogel (ATG) offers effective acromegaly treatment, comparable to octreotide LAR. Its novel formulation and convenient self-injection improve patient care and outcomes.
Area of Science:
- Endocrinology
- Pharmacology
- Drug Delivery Systems
Background:
- Lanreotide autogel (LAN ATG) is a somatostatin analog for acromegaly treatment.
- Limited comparative data existed for LAN ATG versus octreotide (OCT) LAR.
Purpose of the Study:
- To review the development, pharmacokinetics, acceptability, and clinical efficacy of LAN ATG.
- To compare LAN ATG with OCT LAR in acromegaly management.
Main Methods:
- Comprehensive literature review of original studies on LAN ATG.
- Analysis of data on pharmacokinetics, efficacy, and patient preference.
Main Results:
- LAN ATG exhibits pseudo first-order pharmacokinetics due to its nanotubular structure.
- Efficacy is comparable to OCT LAR, normalizing GH and IGF-I in ~60% and ~50% of patients.
- Tumor growth control exceeds 95%, with significant size reduction in 64%.
Conclusions:
- LAN ATG demonstrates equivalent efficacy to OCT LAR for acromegaly.
- The prefilled syringe and 8-week dosing interval enhance patient convenience and self-administration.
- LAN ATG is a strong therapeutic option for acromegaly patients.
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