Treatment of perimacular proliferations in diabetic ophthalmopathy with fluorouracil

Five eyes from 4 diabetic patients with proliferations perimacularly were treated with fluorouracil after previous unsuccessful treatment with laser therapy. Fluorouracil was administered in two series of five injections each, every second day in daily doses of 10 to 15 mg subconjunctivally. Fluorouracil was well tolerated. It has a certain inhibitory effect (both on vessels and particularly on the formation of the accompanying fibers) on proliferations reaching the macula at a distance from the vessels out of reach of the visual disc, it has no suppressing effect on papilloretinal proliferations.