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Related Experiment Videos

Monocyte function and lysozyme activity in cord blood.

N Starobinas1, M M Carneiro-Sampaio

  • 1Instituto de Ciências Biomédicas, Faculdade de Medicina, Universidade de São Paulo, Brazil.

Allergologia Et Immunopathologia
|May 1, 1989
PubMed
Summary

Neonatal monocytes show adult-like responses to chemotaxis and Fc receptors but reduced C3 receptor function. Newborn sera are less effective at stimulating chemotaxis and opsonization, despite higher lysozyme levels.

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[Immune system and infections]

Jornal de pediatria·2003

Area of Science:

  • Immunology
  • Neonatal immunology

Background:

  • The mononuclear phagocytic system's role in neonatal immunocompetence requires further investigation.
  • Understanding early-life immune responses is crucial for infant health.

Purpose of the Study:

  • To analyze the functional capacity of cord blood monocytes in human neonates.
  • To compare neonatal immune responses with those of adult blood donors.

Main Methods:

  • Monocyte chemotaxis assays.
  • Phagocytosis assays using sheep erythrocytes (E) for Fc receptors and Zymosan (Zy) particles for C3 receptors.
  • Evaluation of serum lysozyme activity and chemotactic/opsonizing potential.

Main Results:

  • Neonatal monocytes exhibited chemotactic and Fc receptor-mediated phagocytosis comparable to adult monocytes.

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  • Phagocytosis via C3 receptors was significantly lower in neonates compared to adults.
  • Newborn sera showed reduced ability to generate chemotactic stimuli and opsonize Zymosan particles, despite higher lysozyme concentrations.

    • Conclusions:

    • Neonatal mononuclear phagocytic system demonstrates specific functional deficits, particularly in C3 receptor-mediated phagocytosis.
    • Deficiencies in serum-mediated opsonization and chemotaxis may contribute to altered neonatal immune responses.