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Targeting oncogenes and tumor suppressors genes to mitigate chemoresistance

Tahereh Fatemian, Ezharul Hoque Chowdhury1

  • 1Jeffrey Cheah School of Medicine and Health Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Malaysia. md.ezharul.hoque@monash.edu.

Current Cancer Drug Targets
|October 14, 2014
PubMed

Insights

Cancer cells develop resistance to chemotherapy through transporter malfunctions and signaling disruptions. This review explores using RNA interference to target oncogenes and tumor suppressor genes, aiming to re-sensitize cells to treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Chemotherapy resistance in cancer cells arises from membrane transporter malfunctions and signaling cascade disruptions.
  • These cellular protective mechanisms lead to treatment failure in cancer therapy.
  • Understanding the genetic alterations driving resistance is crucial for developing effective treatments.

Purpose of the Study:

  • To review the use of RNA interference (RNAi) as a tool to investigate genetic alterations in cancer cells.
  • To explore the potential of targeting non-transporter genes, such as oncogenes and tumor suppressor genes, to overcome chemotherapy resistance.
  • To discuss strategies for re-sensitizing cancer cells to therapeutics.

Main Methods:

  • Utilizing RNA interference (RNAi) for gene knockdown to study gene function.
  • Employing small interfering RNA (siRNA) to target specific genes.
  • Analyzing the phenotypic manifestations of targeted gene knockdown.

Main Results:

  • RNA interference serves as a reliable method for probing gene function and validating gene targets.
  • Investigating non-transporter targets, including oncogenes and tumor suppressor genes, is a promising approach.
  • Targeted gene manipulation can potentially re-sensitize cancer cells to chemotherapy.

Conclusions:

  • Dissecting the genetic pathways involved in chemotherapy resistance is essential.
  • RNA interference is a valuable tool for exploring these pathways and identifying therapeutic targets.
  • Targeting oncogenes and tumor suppressor genes may offer a strategy to improve cancer treatment outcomes.

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