Related Experiment Video
Updated: Apr 22, 2026

Effect of Artificial Tear Formulations on the Metabolic Activity of Human Corneal Epithelial Cells after Exposure to Desiccation
Published on: May 2, 2020
Effect of textured eye drop bottles on the photostability of pranoprofen 0.1% ophthalmic solution
Kinya Iwatsuka1, Katsuhiro Inada, Hiroki Ueoka
1a Senju Pharmaceutical Co., Ltd , Nishiku Kobe, Hyogo , Japan.
Context:
Ophthalmic solutions are usually filled in a plastic bottle due to its durability and disposability. In Japan, photostability is one of the concerns for the quality control because an eye drop bottle must be a transparent container.
Objective:
The present work studied the effect of textured eye drop bottles on its light blocking to improve the photostability of ophthalmic solutions.
Materials And Methods:
We investigated the photostability of Pranoprofen ophthalmic solution filled in a variety of textured eye drop bottles. Pranoprofen content was analyzed by high-performance liquid chromatography and surface structure of textured eye drop bottles was evaluated by transmittance, calculated average roughness (Ra) and haze intensity.
Results:
We observed that eye drop bottle which had greater than Ra value of 1.0 µm and haze intensity 62% clearly showed photostability improvement.
Conclusions:
This report is the first one which shows that photostability of ophthalmic solution is improved by using textured eye drop bottle. Moreover, this approach is a simple and effective method to improve the photostability. This method is available for not only various ophthalmic applications but also other liquid pharmaceuticals or food products.
Related Concept Videos
Ophthalmic Drug Delivery Systems
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
Drug Product Stability
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Factors Influencing Drug Absorption: Pharmaceutical Parameters

