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Acute decrease in serum testosterone after a mixed glucose and protein beverage in obese peripubertal boys.

Alexander Schwartz1,2, Barkha P Patel1, Shirley Vien1

  • 1Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Clinical Endocrinology
|October 14, 2014
PubMed
Summary
This summary is machine-generated.

A glucose/protein drink significantly lowered testosterone levels in obese adolescent boys. This decrease was linked to reduced luteinizing hormone (LH) and appetite hormones, suggesting a potential impact on puberty development.

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Area of Science:

  • Endocrinology
  • Pediatric Endocrinology
  • Metabolic Research

Background:

  • Obesity in adolescent males is linked to delayed puberty and lower testosterone (T).
  • In adults, glucose intake acutely reduces serum T, but this effect is unstudied in adolescents.
  • The impact of a mixed beverage on T in obese peripubertal males requires investigation.

Purpose of the Study:

  • To investigate the acute effect of a glucose/protein beverage on serum T concentrations in obese peripubertal males.
  • To determine the relationship between T concentration changes and appetite hormone levels (ghrelin, GLP-1).

Main Methods:

  • A cross-sectional study included 23 overweight/obese males aged 8-17 years, across Tanner stages.
  • Participants consumed a glucose and protein beverage.
  • Blood samples were collected over 60 minutes to measure pubertal hormones, ghrelin, and GLP-1.

Main Results:

  • A significant decrease in T levels (18.6%) was observed in adolescent boys across all pubertal stages.
  • The reduction in T was associated with a decrease in luteinizing hormone (LH).
  • Fasting T was inversely correlated with fasting ghrelin, but not with GLP-1.

Conclusions:

  • Acute intake of a mixed glucose/protein beverage lowers T levels in overweight and obese peripubertal boys.
  • A potential mechanism involves an acute decrease in LH, warranting further study.
  • Appetite hormone levels, particularly ghrelin, may play a role in T regulation in this population.