Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Familial abdominal wall defects.

D W Hershey¹, H C Haesslein, C C Marr

¹Ob/Gyn Genetic Services, Sutter Perinatal Center, Sutter Memorial Hospital, Sacramento, CA 95819.

American Journal of Medical Genetics

|October 1, 1989

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Abortion with Placenta Prœvia and Hydrops Amnii.

The Buffalo medical journal and monthly review of medical and surgical science·2022

Same author

Recombinant hepatitis B vaccine: a review of its immunogenicity and protective efficacy against hepatitis B.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2007

Same author

Lepirudin: a review of its potential place in the management of thrombotic disorders.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2007

Same author

Inhaled salmeterol/fluticasone propionate combination. A pharmacoeconomic review of its use in the management of asthma.

PharmacoEconomics·2001

Same author

Oxaliplatin: a review of its use in the management of metastatic colorectal cancer.

Drugs & aging·1999

Same author

Efavirenz.

Drugs·1999

Same journal

Abstracts for the Xth World Congress of Psychiatric Genetics. Brussels, Belgium, 9-13 October 2002.

American journal of medical genetics·2003

Same journal

Defects of blastogenesis.

American journal of medical genetics·2002

Same journal

Malformations of the craniofacial region: evolutionary, embryonic, genetic, and clinical perspectives.

American journal of medical genetics·2002

Same journal

Limb anomalies: Developmental and evolutionary aspects.

American journal of medical genetics·2002

Same journal

Molecular etiology of gut malformations and diseases.

American journal of medical genetics·2002

Same journal

Status of the human malformation map: 2002.

American journal of medical genetics·2002

See all related articles

Familial abdominal wall defects, including gastroschisis and omphalocele, suggest multifactorial inheritance. This genetic influence may also explain associated bowel atresias in these congenital anomalies.

Area of Science:

Medical Genetics
Developmental Biology
Pediatric Surgery

Background:

Abdominal wall defects are congenital anomalies with varying etiologies.
Gastroschisis and omphalocele are common types of abdominal wall defects.
Understanding the genetic basis of these defects is crucial for diagnosis and counseling.

Observation:

Two families presented with multiple siblings affected by abdominal wall defects.
Family 1: Identical twins (monochorionic, diamniotic) with gastroschisis, a novel occurrence.
Family 2: Siblings with omphalocele, partial colon atresia, and gastroschisis, without associated anomalies.

Findings:

The familial aggregation of gastroschisis, omphalocele, and bowel atresia suggests a genetic component.

Related Experiment Videos

Multifactorial determination is proposed for at least some cases of abdominal wall defects.

Shared genetic factors may underlie gastroschisis, omphalocele, and associated intestinal atresias.

Implications:

These findings support considering multifactorial inheritance in the etiology of abdominal wall defects.
The study highlights a potential genetic link between gastroschisis, omphalocele, and bowel atresias.
Further research into the genetic underpinnings of these conditions is warranted for improved clinical management.