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Biological therapy for ulcerative colitis: an update

Geom Seog Seo1, Soo-Cheon Chae1

  • 1Geom Seog Seo, Department of Gastroenterology, Wonkwang University School of Medicine, Digestive Disease Research Institute, Chonbuk 570-749, South Korea.

World Journal of Gastroenterology
|October 14, 2014
PubMed

Of the diverse biological agents used for patients with ulcerative colitis, the anti-tumor necrosis factor-α agents infliximab and adalimumab have been used in large-scale clinical trials and are currently widely used in the treatment of inflammatory bowel disease patients. Recent studies have indicated that golimumab, oral tofacitinib and vedolizumab reportedly achieved good clinical response and remission rates in ulcerative colitis patients. Thus, we believe that the detailed investigation of various studies on clinical trials may provide important information for the selection of appropriate biological agents, and therefore, we have extensively reviewed such trials in the present study.

Keywords:
Biological therapyClinical trialImmune dysfunctionInflammatory bowel diseaseRemissionUlcerative colitis

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